| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38713345 | Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol |
| Curcumin | 📋 | ✍ | ⛔ | | 38629652 | Effects of curcumin supplementation on abdominal surgical wound healing |
| Vitamin C | 📋 | ✍ | ⛔ | | 38693699 | Efficacy and safety of mesotherapy with tranexamic acid versus vitamin C in the treatment of melasma: A meta-analysis and systemic review |
| Aloe Vera | 📋 | ✍ | ⛔ | | 38605441 | Effects of aloe vera on burn injuries: A systematic review and meta-analysis of randomized controlled trials |
| Resveratrol | 📋 | ✍ | ⛔ | | 38592565 | Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38389423 | Ginsenoside Compound K Reduces Psoriasis-related Inflammation by Activation of the Glucocorticoid Receptor in Keratinocytes |
| Medicinal Plants | 📋 | | | | 38715699 | A Narrative Review of Herbal Remedies for Managing Hirsutism |
| Melatonin | 📋 | ✍ | ⛔ | | 38653920 | Melatonin Attenuates Imiquimod-Induced Psoriasis-Like Inflammation and Restores the Th17/Treg Immune Balance |
| Polypodium Leucotomos | 📋 | ✍ | ⛔ | | 36892441 | The combination of oral and topical photoprotection with a standardized Polypodium leucotomos extract is beneficial against actinic keratosis |
| EGCG | 📋 | ✍ | ⛔ | | 38304421 | Photoprotective Effects of Epigallocatechin Gallate on Ultraviolet-Induced Zebrafish and Human Skin Fibroblasts Cells |
| Micronutrients | 📋 | | ⛔ | | 38732239 | An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy |
| Quercetin | 📋 | ✍ | ⛔ | | 38688383 | Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1 |
| Apigenin | 📋 | ✍ | ⛔ | | 38261238 | Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38601151 | Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris |
| Ginseng | 📋 | ✍ | ⛔ | | 38449662 | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| Nicotinamide | 📋 | ✍ | ⛔ | | 38671873 | Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 38009035 | Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test |
| Vitamin E | 📋 | ✍ | ⛔ | | 38284201 | Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure |
| Honey | 📋 | ✍ | ⛔ | | 38013499 | Honey therapies for dermatological disorders: more than just a sweet elixir |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38695248 | Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38151671 | Applications of propolis-based materials in wound healing |
| Zinc | 📋 | ✍ | ⛔ | | 38612631 | Zinc, Copper, and Iron in Selected Skin Diseases |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38007430 | Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling |
| Metformin | 📋 | ✍ | ⛔ | | 38623111 | The Efficacy of Metformin as a Therapeutic Agent in the Treatment of Acne Vulgaris: A Systematic Review |
| Phytochemicals | 📋 | | | | 38399428 | Recent Advances in the Management of Rosacea through Natural Compounds |
| Collagen | 📋 | ✍ | | | 38612608 | Research Progress on Bioactive Factors against Skin Aging |
| Fucoidan | 📋 | ✍ | ⛔ | | 38186578 | Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway |
| Gotu Kola | 📋 | ✍ | ⛔ | | 37295572 | Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study |
| Licorice Root | 📋 | ✍ | ⛔ | | 38391417 | In Vitro Release of Glycyrrhiza Glabra Extract by a Gel-Based Microneedle Patch for Psoriasis Treatment |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38027999 | Potential roles of circulating microRNAs in the healing of type 1 diabetic wounds treated with green tea extract: molecular and biochemical study |
| Berberine | 📋 | ✍ | ⛔ | | 38249466 | The antibacterial activity of berberine against Cutibacterium acnes: its therapeutic potential in inflammatory acne |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38676310 | Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene |
| Vitamin A | 📋 | ✍ | ⛔ | | 38643459 | Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging |
| Fish Collagen | 📋 | ✍ | ⛔ | | 38667776 | Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging |
| Luteolin | 📋 | ✍ | ⛔ | | 37609830 | Luteolin photo-protects zebrafish from environmental stressor ultraviolet radiation (UVB) |
| Probiotics | 📋 | ✍ | ⛔ | | 38340656 | Immunological aspects of probiotics for improving skin diseases: Influence on the Gut-Brain-Skin Axis |
| Pomegranate | 📋 | | ⛔ | | 38675119 | Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin |
| Fisetin | 📋 | ✍ | ⛔ | | 38139186 | Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes |
| Essential Oils | 📋 | | ⛔ | | 38625386 | The use of essential oils in atopic dermatitis: a review |
| Food | 📋 | | | | 38018738 | The importance of diet in psoriasis |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37858664 | Grape seed proanthocyanidins regulate mitophagy of endothelial cells and promote wound healing in mice through p-JNK/FOXO3a/ROS signal pathway |
| Lycopene | 📋 | ✍ | ⛔ | | 37493553 | [Lycopene – the impact of supplementation on the skin aging process] |
| Marigold | 📋 | ✍ | ⛔ | | 38595380 | Efficacy of Topical Turmeric, Calendula officinalis, and Tulsi (Ayurvedic Gel) in the Management of Erosive Lichen Planus: A Placebo-Controlled Study |
| Olive Oil | 📋 | ✍ | ⛔ | | 37432217 | The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts |
| Pine Bark | 📋 | ✍ | ⛔ | | 38592434 | Pycnogenol® prevents skin hyperpigmentation following sclerotherapy |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 35153762 | P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-κB and STAT3 Pathways |
| Genistein | 📋 | ✍ | ⛔ | | 36835861 | Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38037612 | Isothiocyanate-rich moringa seed extract reduces skin inflammation in mouse ear edema model |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 38370085 | Anti-skin aging effect of sea buckthorn proanthocyanidins in D-galactose-induced aging mice |
| Bromelain | 📋 | ✍ | ⛔ | | 36971218 | Bromelain: a candidate to enhance wound healing after endonasal surgeries |
| Hesperidin | 📋 | ✍ | ⛔ | | 38339165 | Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview |
| Astragalosides | 📋 | ✍ | ⛔ | | 38533358 | Effect of total astragalosides on diabetic non-healing wound by regulating immune microenvironment |
| CoQ10 | 📋 | ✍ | ⛔ | | 37480004 | Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38685364 | Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway |
| Naringenin | 📋 | ✍ | ⛔ | | 38423648 | Naringenin Induces Cellular Apoptosis in Melanoma Cells via Intracellular ROS Generation |
| Baicalin | 📋 | ✍ | ⛔ | | 37929119 | Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway |
| Goji Berry | 📋 | ✍ | ⛔ | | 37957869 | Preparation of Lycium Barbarum Active Glycopeptide and Investigation of Its Apoptotic Effects on Melanoma |
| L-Arginine | 📋 | ✍ | ⛔ | | 38426801 | L-arginine supplementation abrogates hypoxia-induced virulence of Staphylococcus aureus in a murine diabetic pressure wound model |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38510374 | Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds |
| Rosmarinic Acid | 📋 | ✍ | | | 38470170 | Rosemary extract and rosmarinic acid accelerate elastic fiber formation by increasing the expression of elastic fiber components in dermal fibroblasts |
| Silymarin | 📋 | ✍ | ⛔ | | 38684022 | Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation |
| St. Johns Wort Oil | 📋 | | ⛔ | | 36984468 | Combination of St. John's Wort Oil and Neem Oil in Pharmaceuticals: An Effective Treatment Option for Pressure Ulcers in Intensive Care Units |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38390059 | Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38645438 | Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 38725079 | Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin-induced apoptosis of melanoma cells |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38641701 | Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study |
| Rosemary | 📋 | ✍ | ⛔ | | 38565924 | Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 37265686 | Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 36908902 | Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study |
| Rutin | 📋 | ✍ | ⛔ | | 38149569 | Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence |
| Silibinin | 📋 | ✍ | | | 37762688 | Silibinin Downregulates Types I and III Collagen Expression via Suppression of the mTOR Signaling Pathway |
| Turmeric | 📋 | ✍ | ⛔ | | 38595380 | Efficacy of Topical Turmeric, Calendula officinalis, and Tulsi (Ayurvedic Gel) in the Management of Erosive Lichen Planus: A Placebo-Controlled Study |
| Cocoa | 📋 | ✍ | ⛔ | | 36332189 | Cocoa presents cytotoxicity against melanoma cancer cell lines (A-375 e B16-F10) and improves chemotherapy activity by increasing oxidative stress |
| Galangin | 📋 | | | | 35163314 | Galangin Reverses H 2 O 2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling |
| Indian Gooseberry | 📋 | | ⛔ | | 37487962 | The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: A randomized controlled trial |
| Selenium | 📋 | ✍ | ⛔ | | 38681430 | Safety, Efficacy and Attributes of 2.5% Selenium Sulfide Shampoo in the Treatment of Dandruff: A Single-Center Study |
| Antioxidants | 📋 | | ⛔ | | 38612608 | Research Progress on Bioactive Factors against Skin Aging |
| Baicalein | 📋 | ✍ | ⛔ | | 37434796 | Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells |
| Kaempferol | 📋 | ✍ | ⛔ | | 37951194 | Harmine and Kaempferol treatment enhances NFATC1 and FOXP3 mediated regulatory T-cells' suppressive capacity in generalized vitiligo |
| Salidroside | 📋 | | | | 38588875 | Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production |
| Allicin | 📋 | ✍ | ⛔ | | 38308387 | Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models |
| Bee Venom | 📋 | ✍ | ⛔ | | 38672762 | Natural Sources of Therapeutic Agents Used in Skin Conditions |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38091639 | Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38643459 | Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38427125 | Effectiveness of glutamine for the treatment of radiodermatitis in cancer patients: a meta-analysis of randomized controlled trials |
| Neem | 📋 | ✍ | | | 38565924 | Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 36222190 | Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition |
| Peony | 📋 | | ⛔ | | 38579646 | Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. Flower via network pharmacology-HPLC integration |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 36946749 | A Randomized Split-Face Study of Photodynamic Therapy With St. John's Wort and Indole-3-Acetic Acid for the Treatment of Acne |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 37371994 | Tea Tree Oil: Properties and the Therapeutic Approach to Acne-A Review |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38233029 | Folic Acid and Diabetic Foot Ulcers |
| Angelica | 📋 | ✍ | ⛔ | | 38154523 | Sophora flavescens-Angelica sinensis in the treatment of eczema by inhibiting TLR4/MyD88/NF-κB pathway |
| Blueberry | 📋 | ✍ | ⛔ | | 38255297 | Role of a Polyphenol-Enriched Blueberry Preparation on Inhibition of Melanoma Cancer Stem Cells and Modulation of MicroRNAs |
| Cinnamon | 📋 | ✍ | ⛔ | | 37998718 | Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway |
| Coconut Oil | 📋 | | ⛔ | | 37518923 | Effectiveness of Virgin Coconut Oil and Regular Repositioning in Preventing Pressure Ulcers in Children |
| Gallic Acid | 📋 | | ⛔ | | 38004381 | Gallic Acid Treats Hypertrophic Scar in Rabbit Ears via the TGF-β/Smad and TRPC3 Signaling Pathways |
| NMN | 📋 | ✍ | ⛔ | | 38398550 | β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress |
| Retinoic Acid | 📋 | | | | 38629345 | Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia |
| Capsaicin | 📋 | ✍ | ⛔ | | 37387413 | Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process |
| Cinnamaldehyde | 📋 | | | | 37275806 | Anti-Inflammatory Effect of Cinnamaldehyde in a Mouse Model of 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis |
| Echinacea | 📋 | ✍ | ⛔ | | 36770844 | Extraction Optimization, Antioxidant, Cosmeceutical and Wound Healing Potential of Echinacea purpurea Glycerolic Extracts |
| Emodin | 📋 | | ⛔ | | 38062074 | Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes |
| Hesperetin | 📋 | | | | 38263133 | Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice |
| Neem Oil | 📋 | ✍ | ⛔ | | 37151484 | Formulation of Neem Leaf and Croton Seed Essential Oils as a Natural Insecticide Tested on Mosquitoes and Cockroaches |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38706837 | Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells |
| Salicylic Acid | 📋 | ✍ | ⛔ | | 37942562 | Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial |
| Spirulina | 📋 | ✍ | ⛔ | | 35427427 | The potential application of Spirulina in dermatology |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 35832851 | Relationships of Serum Homocysteine, Vitamin B 12, and Folic Acid Levels with Papulopustular Rosacea Severity: A Case-Control Study |
| Andrographolide | 📋 | | | | 38712377 | The Potential Anti-psoriatic Effects of Andrographolide: A Comparative Study to Topical Corticosteroids |
| Asiaticoside | 📋 | | | | 37783408 | Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway |
| Chamomile | 📋 | ✍ | ⛔ | | 34658853 | The Mechanism Action of German Chamomile ( Matricaria recutita L.) in the Treatment of Eczema: Based on Dose-Effect Weight Coefficient Network Pharmacology |
| Chrysin | 📋 | ✍ | ⛔ | | 37371032 | Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma |
| Diosmin | 📋 | ✍ | ⛔ | | 38298753 | Stasis Dermatitis: Pathophysiology, Current Treatment Paradigms, and the Use of the Flavonoid Diosmin |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 35405955 | Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 38444163 | Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis |
| Iodine | 📋 | ✍ | ⛔ | | 37765236 | Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds |
| Licochalcones | 📋 | | | | 38152154 | Efficacy and Tolerability of a Sunscreen Containing Licochalcone a and L-Carnitine as an Adjunct to Retinoids in the Management of Acne and Post-Acne Pigmentation Among Malaysian Patients |
| Mulberry | 📋 | | ⛔ | | 38219884 | Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis |
| Myrtle | 📋 | ✍ | ⛔ | | 33408898 | The Effects of Myrtle ( Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study |
| Onion | 📋 | ✍ | ⛔ | | 38146392 | Formulation and Evaluation of Herbal-Based Antiacne Gel Preparations |
| Puerarin | 📋 | ✍ | ⛔ | | 36568527 | Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38004322 | Protective Effect of Urtica dioica Extract against Oxidative Stress in Human Skin Fibroblasts |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 34917538 | Repellent Efficacy of Eucalyptus globulus and Syzygium aromaticum Essential Oils against Malaria Vector, Anopheles stephensi (Diptera: Culicidae) |
| Fig | 📋 | | ⛔ | | 38672762 | Natural Sources of Therapeutic Agents Used in Skin Conditions |
| Fish Oil | 📋 | ✍ | ⛔ | | 37744329 | Herring roe oil in treatment of psoriasis - influence on immune cells and cytokine network |
| Frankincense | 📋 | ✍ | ⛔ | | 35778893 | Evaluation of antibacterial and wound healing activities of alcoholic extract of Boswellia carterii, in vitro and in vivo study |
| Piperine | 📋 | ✍ | ⛔ | | 38472966 | Vitiligo Treated with Combined Piperine-Based Topical Treatment and Narrowband Ultraviolet B Therapy: Follow-Up with Reflectance Confocal Microscopy |
| Polyphenols | 📋 | | | | 38398617 | The Promising Role of Polyphenols in Skin Disorders |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 35447441 | Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice |
| Punicalagin | 📋 | ✍ | ⛔ | | 38367463 | Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway |
| Senolytics | 📋 | | | | 38074322 | The role of cellular senescence in skin aging and age-related skin pathologies |
| Skullcap | 📋 | ✍ | ⛔ | | 38543055 | Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction |
| Acemannan | 📋 | | | | 33854714 | Acemannan-induced tooth socket healing: A 12-month randomized controlled trial |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 36077254 | Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice |
| Cat's Claw | 📋 | ✍ | ⛔ | | 33670520 | Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours |
| Coffee | 📋 | ✍ | ⛔ | | 38178620 | Beverage consumption and facial skin aging: Evidence from Mendelian randomization analysis |
| Diosmetin | 📋 | | | | 35955819 | Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 33511202 | Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy |
| Grape | 📋 | | ⛔ | | 36741360 | Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC/NgaTndCrlj mice |
| Hydroxytyrosol | 📋 | | | | 36985625 | The Effect of Hydroxytyrosol in Type II Epithelial-Mesenchymal Transition in Human Skin Wound Healing |
| Kiwifruit | 📋 | ✍ | ⛔ | | 36989426 | Evaluation of the wound-healing potential of the kiwifruit extract by assessing its effects on human gingival fibroblasts and angiogenesis |
| MSM | 📋 | ✍ | ⛔ | | 36591763 | EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE |
| Naringin | 📋 | ✍ | ⛔ | | 38019336 | In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431) |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35625193 | An Up-To-Date Review Regarding Cutaneous Benefits of Origanum vulgare L. Essential Oil |
| Rehmannia | 📋 | ✍ | ⛔ | | 35168697 | Anti-atopic dermatitis effects of Parasenecio auriculatus via simultaneous inhibition of multiple inflammatory pathways |
| Roselle | 📋 | ✍ | ⛔ | | 37446030 | Comparative Analysis of Water Extracts from Roselle ( Hibiscus sabdariffa L.) Plants and Callus Cells: Constituents, Effects on Human Skin Cells, and Transcriptome Profiles |
| Saffron | 📋 | ✍ | ⛔ | | 33973339 | Optimization of the saffron compound essence formula and its effect on preventing skin photoaging |
| Aloe-Emodin | 📋 | | | | 37491200 | Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance |
| Andrographis | 📋 | ✍ | ⛔ | | 35369604 | Treatment efficacy of Thunbergia laurifolia, Curcuma longa, Garcinia mangostana, and Andrographis paniculata extracts in Staphylococcus aureus-induced rabbit dermatitis model |
| Apple | 📋 | | ⛔ | | 36547089 | An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice |
| Argan Oil | 📋 | ✍ | ⛔ | | 36235295 | Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38035407 | Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages |
| Black Ginger | 📋 | ✍ | ⛔ | | 36904043 | Methoxyflavones from Black Ginger ( Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells |
| Catechins | 📋 | | | | 37446194 | EGCG, GCG, TFDG, or TSA Inhibiting Melanin Synthesis by Downregulating MC1R Expression |
| Clove Essential Oil | 📋 | | ⛔ | | 36928838 | Repellent Screening of Selected Plant Essential Oils Against Dengue Fever Mosquitoes Using Behavior Bioassays |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 38500495 | Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin |
| Dihydroquercetin | 📋 | | | | 37995531 | Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38526128 | The ω-3 polyunsaturated fatty acid docosahexaenoic acid enhances NK-cell antitumor effector functions |
| Gardenia | 📋 | | ⛔ | | 36980282 | Topical Administration of Gardenia jasminoides Extract Regulates Th2 Immunity in OVA-Induced Mice |
| Gingerol | 📋 | ✍ | | | 37076965 | Investigation on the Anticancer Activity of [6]-Gingerol of Zingiber officinale and its Structural Analogs against Skin Cancer |
| Helichrysum | 📋 | | ⛔ | | 38731954 | Effect of Helichrysum italicum in Promoting Collagen Deposition and Skin Regeneration in a New Dynamic Model of Skin Wound Healing |
| Isoliquiritigenin | 📋 | | | | 37863326 | Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway |
| L-Carnosine | 📋 | ✍ | ⛔ | | 37675862 | Evaluation of human skin response to solar-simulated radiation in an ex vivo model: Effects and photoprotection of L-Carnosine |
| Lotus | 📋 | | ⛔ | | 38449662 | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| Magnesium | 📋 | ✍ | ⛔ | | 38732212 | Unraveling the Mechanisms Involved in the Beneficial Effects of Magnesium Treatment on Skin Wound Healing |
| Mangiferin | 📋 | | ⛔ | | 38621336 | Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis |
| Mangosteen | 📋 | ✍ | ⛔ | | 38549398 | In silico studies on the anti-acne potential of Garcinia mangostana xanthones and benzophenones |
| Myrrh | 📋 | ✍ | ⛔ | | 36015092 | The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy |
| Oleuropein | 📋 | | | | 36050634 | Oleuropein inhibits invasion of squamous cell carcinoma of the head and neck through TGF-β1 signaling pathway |
| Olive Polyphenols | 📋 | | | | 34359512 | Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing |
| Paeoniflorin | 📋 | | | | 37288793 | Paeoniflorin found in Paeonia lactiflora root extract inhibits melanogenesis by regulating melanin-related signal transduction in B16F10 cells |
| Paeonol | 📋 | | | | 37641806 | Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats |
| Procyanidins | 📋 | | ⛔ | | 35719159 | Effectiveness of Dietary Supplement for Skin Moisturizing in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 38021422 | Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects - A 16-Week Randomized, Placebo-Controlled Study |
| Walnut | 📋 | | ⛔ | | 36449813 | Walnut ointment promotes full-thickness burning wound healing: role of linoleic acid |
| Ashwagandha | 📋 | ✍ | ⛔ | | 38185262 | Withania somnifera root extract inhibits MGO-induced skin fibroblast cells dysfunction via ECM-integrin interaction |
| Black Tea | 📋 | ✍ | ⛔ | | 36061029 | Prevention of inorganic arsenic induced squamous cell carcinoma of the skin in Swiss albino mice by black tea through epigenetic modulation |
| Blackcurrant | 📋 | ✍ | ⛔ | | 30939852 | Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats |
| Burdock | 📋 | | ⛔ | | 32412894 | The management of paediatric burns with Burns and Wounds ointment and burdock leaves: a case series |
| Carotenoids | 📋 | ✍ | ⛔ | | 36615749 | A Scoping Review on the Effects of Carotenoids and Flavonoids on Skin Damage Due to Ultraviolet Radiation |
| Chokeberry | 📋 | ✍ | ⛔ | | 37049743 | Fermented Aronia melanocarpa Inhibits Melanogenesis through Dual Mechanisms of the PI3K/AKT/GSK-3β and PKA/CREB Pathways |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 37298745 | Analysis of Essential Oils Components from Aromatic Plants Using Headspace Repellent Method against Aedes aegypti Mosquitoes |
| DMAE | 📋 | ✍ | ⛔ | | 25133239 | Effects of dimethylaminoethanol and compound amino acid on D-galactose induced skin aging model of rat |
| Elderberry | 📋 | ✍ | ⛔ | | 37979821 | Wound healing potential of extract from Sambucus nigra L. leaves and its fractions |
| Emu Oil | 📋 | ✍ | ⛔ | | 28848357 | Emu oil-based lotion effects on neonatal skin barrier during transition from intrauterine to extrauterine life |
| Eucalyptus | 📋 | ✍ | ⛔ | | 38146392 | Formulation and Evaluation of Herbal-Based Antiacne Gel Preparations |
| Graviola | 📋 | ✍ | ⛔ | | 33511059 | Evaluation of wound healing activity of ethanol extract of Annona reticulata L. leaf both in vitro and in diabetic mice model |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38152154 | Efficacy and Tolerability of a Sunscreen Containing Licochalcone a and L-Carnitine as an Adjunct to Retinoids in the Management of Acne and Post-Acne Pigmentation Among Malaysian Patients |
| Milk Thistle | 📋 | ✍ | ⛔ | | 37675655 | Evaluation of efficacy of Silybum marianum flower extract on the mitigating hair loss in vitro and in vivo |
| Persimmon | 📋 | | ⛔ | | 33805791 | Effects of a High-Molecular-Weight Polysaccharides Isolated from Korean Persimmon on the Antioxidant, Anti-Inflammatory, and Antiwrinkle Activity |
| Raspberry | 📋 | ✍ | ⛔ | | 35179167 | Alleviation effects of Rubus coreanus Miquel root extract on skin symptoms and inflammation in chronic atopic dermatitis |
| Salvianolic Acid | 📋 | | | | 38616888 | Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and Dermal Papilla Cells |
| Thymoquinone | 📋 | | ⛔ | | 37998744 | How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets |
| Tomato | 📋 | | ⛔ | | 36606553 | The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38672088 | Ursolic Acid Formulations Effectively Induce Apoptosis and Limit Inflammation in the Psoriasis Models In Vitro |
| Acai Berry | 📋 | ✍ | ⛔ | | 36614291 | Açai Berry Administration Promotes Wound Healing through Wnt/β-Catenin Pathway |
| Anise | 📋 | ✍ | ⛔ | | 36971216 | Efficacy and toxicity of anise oil as a potential topical wound healer: a cell culture study |
| Arnica | 📋 | ✍ | ⛔ | | 35984685 | Arnica montana L. extract containing 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin |
| Asiatic Acid | 📋 | | | | 36837896 | Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential |
| Caffeine | 📋 | ✍ | ⛔ | | 38099120 | Caffeine in Skincare: Its Role in Skin Cancer, Sun Protection, and Cosmetics |
| Camellia | 📋 | | ⛔ | | 36411959 | Assessment of the anti-hair loss potential of Camellia japonica fruit shell extract in vitro |
| Clove | 📋 | | ⛔ | | 36047244 | Bioassay-guided Fractionation of Clove Buds Extract Identifies Eugenol as Potent Melanogenic Inducer in Melanoma Cells |
| Crocin | 📋 | ✍ | ⛔ | | 37284388 | Investigation of the Ability of Crocin to Treat Skin Cancer Chemically Induced in Mice via the Inhibition of the Wnt/β-Catenin and Fibrotic Pathway |
| Glycolic Acid | 📋 | ✍ | ⛔ | | 35182003 | Efficacy and Safety of 5% Glycolic Acid-based Gel Essence in the Treatment of Mild to Moderate Acne |
| Haritaki | 📋 | ✍ | ⛔ | | 37012894 | Evaluation of the efficacy of topical Terminalia chebula Retz. with vinegar in the treatment of tinea corporis: a non-inferiority randomized controlled trial |
| Honokiol | 📋 | | | | 38043155 | Inhibition of Ca2+-permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 38181031 | Aromatic oil from lavender as an atopic dermatitis suppressant |
| Lemon Balm | 📋 | ✍ | ⛔ | | 33921730 | Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters |
| Magnolol | 📋 | | | | 38541664 | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| Mint | 📋 | | ⛔ | | 37416794 | AGEs Blockerâ„¢ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice |
| Papaya | 📋 | ✍ | ⛔ | | 37842248 | Unripe Carica papaya Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts |
| Pumpkin | 📋 | | ⛔ | | 36687694 | Comparative assessment of Cucurbita moschata seed polypeptides toward the protection of human skin cells against oxidative stress-induced aging |
| Schisandra | 📋 | ✍ | ⛔ | | 37580939 | Topical application of cream containing enriched-schizandrin from Schisandra chinensis fruit exert anti-photoaging efficacy in ultraviolet B-irradicated hairless mice |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 38158096 | Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport |
| Vitamins | 📋 | | | | 38695936 | The role of vitamins and nutrients in rosacea |
| White Fungus | 📋 | | | | 37458972 | Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2 |
| Withaferin A | 📋 | | | | 35116997 | Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation |
| Wormwood | 📋 | ✍ | ⛔ | | 37604330 | In vitro and in vivo anti-eczema effect of Artemisia annua aqueous extract and its component profiling |
| Anthocyanins | 📋 | ✍ | ⛔ | | 32916849 | Anthocyanins, Vibrant Color Pigments, and Their Role in Skin Cancer Prevention |
| Arctigenin | 📋 | | | | 38368128 | Arctigenin Induces Apoptosis in Melanoma Cells by Reducing the Expression of BCL-2 and VEGF |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38171680 | β-Glucans obtained from fungus for wound healing: A review |
| Butyrate | 📋 | | ⛔ | | 38159175 | Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38222858 | Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway |
| Chitosan | 📋 | ✍ | ⛔ | | 38161006 | Pharmaceutical applications of chitosan in skin regeneration: A review |
| Chondroitin | 📋 | ✍ | ⛔ | | 37173033 | Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 31695958 | Effect of Chrysanthemum indicum Linné extract on melanogenesis through regulation of TGF-β/JNK signaling pathway |
| Citronella Essential Oil | 📋 | ✍ | ⛔ | | 36223259 | Alternatives to Pyrethroid Resistance: Combinations of Cymbopogon nardus and Ocimum americanum Essential Oils Improve the Bioefficiency Control Against the Adults' Populations of Aedes aegypti (Diptera: Culicidae) |
| Coconut | 📋 | | ⛔ | | 38665592 | Impact of coconut kernel extract on carcinogen-induced skin cancer model: Oxidative stress, C-MYC proto-oncogene and tumor formation |
| Copper | 📋 | ✍ | ⛔ | | 38612631 | Zinc, Copper, and Iron in Selected Skin Diseases |
| Cordyceps | 📋 | ✍ | ⛔ | | 38673866 | NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity |
| Dandelion | 📋 | ✍ | ⛔ | | 35128947 | Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway |
| Dihydroartemisinin | 📋 | | | | 37982352 | Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis |
| DIM | 📋 | ✍ | ⛔ | | 38602626 | 3,3'-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice |
| Dioscin | 📋 | | | | 36610151 | Dioscin induces M1 macrophage polarization through Connexin-43 Channels in Tumor-associated-macrophages-mediated melanoma metastasis |
| Eugenol | 📋 | | | | 38397766 | Revitalizing Photoaging Skin through Eugenol in UVB-Exposed Hairless Mice: Mechanistic Insights from Integrated Multi-Omics |
| Flavonoids | 📋 | | ⛔ | | 37047297 | Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases |
| Formononetin | 📋 | | | | 38579666 | Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway |
| Galangal | 📋 | ✍ | ⛔ | | 36123596 | Alpinia officinarum Rhizome ameliorates the UVB induced photoaging through attenuating the phosphorylation of AKT and ERK |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 38061964 | Associations of serum gamma-linolenic acid levels with erythema severity and anxiety/depression status in patients with rosacea |
| Geranium Essential Oil | 📋 | | ⛔ | | 38672762 | Natural Sources of Therapeutic Agents Used in Skin Conditions |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 31003677 | Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 35140283 | The fabrication and assessment of mosquito repellent cream for outdoor protection |
| Mastic | 📋 | ✍ | ⛔ | | 37796709 | Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38676310 | Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene |
| Nobiletin | 📋 | ✍ | | | 35350242 | Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway |
| Orange | 📋 | | ⛔ | | 35684041 | Photoprotective and Antiaging Effects of a Standardized Red Orange ( Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study |
| Patchouli | 📋 | ✍ | ⛔ | | 37298745 | Analysis of Essential Oils Components from Aromatic Plants Using Headspace Repellent Method against Aedes aegypti Mosquitoes |
| Prebiotics | 📋 | ✍ | ⛔ | | 38312314 | Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review |
| Quercitrin | 📋 | | | | 35204104 | Hyperoside and Quercitrin in Houttuynia cordata Extract Attenuate UVB-Induced Human Keratinocyte Cell Damage and Oxidative Stress via Modulation of MAPKs and Akt Signaling Pathway |
| Rapamycin | 📋 | ✍ | | | 38385108 | Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway |
| Sage | 📋 | ✍ | ⛔ | | 35157797 | Antitumor Effect of Manool in a Murine Melanoma Model |
| Tanshinone | 📋 | | | | 38284293 | Tanshinone IIA, a component of the self-made Xiao-Yin decoction, ameliorates psoriasis by inhibiting IL-17/IL-23 and PTGS2/NF-κB/AP-1 pathways |
| Witch Hazel | 📋 | ✍ | ⛔ | | 38179008 | Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel ( Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia |
| Withanolides | 📋 | | | | 34875348 | Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation |
| Almond Oil | 📋 | | ⛔ | | 34957578 | An updated review on efficacy and benefits of sweet almond, evening primrose and jojoba oils in skin care applications |
| Aloin | 📋 | | | | 32565850 | Enhancement of the Anti-Skin Wrinkling Effects of Aloe arborescens Miller Extracts Associated With Lactic Acid Fermentation |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 35563819 | Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model |
| Apple Polyphenols | 📋 | | ⛔ | | 35739968 | Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients |
| Arctiin | 📋 | | | | 28990056 | Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis |
| Aspirin | 📋 | | ⛔ | | 36660204 | The Association Between Aspirin and Basal Cell Carcinoma: A Clinical and Financial Analysis |
| Balloon Flower | 📋 | ✍ | ⛔ | | 37187105 | Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 32726891 | β-Carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in B16F-10 melanoma cells |
| Beta-Lapachone | 📋 | | | | 29434949 | Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines |
| Betulinic Acid | 📋 | | | | 36430989 | Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells |
| Black Pepper | 📋 | ✍ | ⛔ | | 37464192 | Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma |
| Calcium | 📋 | ✍ | ⛔ | | 35088227 | Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome |
| Calycosin | 📋 | | | | 38331120 | Calycosin enhances treg differentiation for alleviating skin inflammation in atopic dermatitis |
| Carnosic Acid | 📋 | | | | 36358539 | Paradoxical Radiosensitizing Effect of Carnosic Acid on B16F10 Metastatic Melanoma Cells: A New Treatment Strategy |
| Carrot | 📋 | | ⛔ | | 31442148 | Repellent Activity of Carrot Seed Essential Oil and Its Pure Compound, Carotol, Against Mosquitoes |
| Carvacrol | 📋 | ✍ | ⛔ | | 35806123 | A Combination of the Natural Molecules Gallic Acid and Carvacrol Eradicates P. aeruginosa and S. aureus Mature Biofilms |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 33206422 | Topical Application with Conjugated Linoleic Acid Ameliorates 2, 4-dinitrofluorobenzene-Induced Atopic Dermatitis-like Lesions in BALB/c Mice |
| Coptis Chinensis | 📋 | | ⛔ | | 35209199 | Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice |
| Cryptotanshinone | 📋 | | | | 38454519 | Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma |
| D-Mannose | 📋 | ✍ | ⛔ | | 37001381 | d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 37759812 | Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells |
| Elastin | 📋 | ✍ | | | 38483134 | Elastin and collagen fibres in cutaneous wound healing |
| Escin | 📋 | ✍ | ⛔ | | 37504289 | Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 36818058 | Effects of Flaxseed Oil and Olive Oil on Markers of Inflammation and Wound Healing in Burn Patients: A Randomized Clinical Trial |
| Garlic | 📋 | ✍ | ⛔ | | 36331804 | Therapeutic applications of garlic and turmeric for the diabetic wound healing in mice |
| Geraniol | 📋 | | | | 37516088 | Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling |
| Glabridin | 📋 | | | | 38497297 | Effect of glabridin combined with bakuchiol on UVB-induced skin damage and its underlying mechanism: An experimental study |
| Holy Basil | 📋 | ✍ | ⛔ | | 38595380 | Efficacy of Topical Turmeric, Calendula officinalis, and Tulsi (Ayurvedic Gel) in the Management of Erosive Lichen Planus: A Placebo-Controlled Study |
| Honeysuckle | 📋 | | ⛔ | | 38731465 | Pharmacological Activities of Lonicerae japonicae flos and Its Derivative-"Chrysoeriol" in Skin Diseases |
| Iron | 📋 | ✍ | ⛔ | | 38612631 | Zinc, Copper, and Iron in Selected Skin Diseases |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 36313379 | The effects of aqueous extract of Labisia Pumila (Blume) Fern.-Vill. Var. Alata on wound contraction, hydroxyproline content and histological assessments in superficial partial thickness of second-degree burn model |
| Knotweed | 📋 | ✍ | ⛔ | | 32714420 | Polygonum multiflorum Thunb. Extract Stimulates Melanogenesis by Induction of COX2 Expression through the Activation of p38 MAPK in B16F10 Mouse Melanoma Cells |
| Kudzu Root | 📋 | ✍ | ⛔ | | 38288763 | Photoprotective effects of Lithospermum erythrorhizon and Pueraria lobata extracts on UVB-induced photoaging: A study on skin barrier protection |
| Liquiritin | 📋 | | | | 37849425 | Liquiritin targeting Th17 cells differentiation and abnormal proliferation of keratinocytes alleviates psoriasis via NF-κB and AP-1 pathway |
| Lupeol | 📋 | | | | 37098554 | Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice |
| Madecassoside | 📋 | | | | 37976111 | Synergistic Effect of Madecassoside and Rosmarinic Acid Against Ultraviolet B-Induced Photoaging in Human Skin Fibroblasts |
| Mango | 📋 | | ⛔ | | 35897945 | Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes |
| Myricetin | 📋 | | ⛔ | | 36649930 | Myricetin alleviated immunologic contact urticaria and mast cell degranulation via the PI3K/Akt/NF-κB pathway |
| Oak Bark | 📋 | ✍ | ⛔ | | 31630959 | Endemic North American Plants as Potentially Suitable Agents for Wound Cleaning Under Resource Scarce Conditions |
| Oleanolic Acid | 📋 | | | | 38192424 | Oleanolic acid rescues critical features of umbilical vein endothelial cells permanently affected by hyperglycemia |
| Pectin | 📋 | ✍ | ⛔ | | 38417857 | Oral Administration of Apple Pectin Solution Improves Atopic Dermatitis in a Mouse Model |
| Prickly Pear | 📋 | | ⛔ | | 37991201 | Anti-inflammatory and healing effect of the polysaccharidic extract of Opuntia ficus-indica cladodes in cutaneous excisional wounds in rats |
| Royal Jelly | 📋 | ✍ | ⛔ | | 37679248 | The effect of oral treatment of royal jelly on the expression of the PDGF-β gene in the skin wound of male mice |
| Seaweeds | 📋 | | ⛔ | | 38450959 | A pilot study on the efficacy of a seaweed mud application in the treatment of cellulite |
| Sesame Oil | 📋 | | ⛔ | | 37620987 | Efficacy of sesame oil versus placebo in the management of acute radiation-induced dermatitis in breast cancer patients: A double-blind randomized clinical trial |
| Shogaol | 📋 | | | | 32429495 | 6-Shogaol Protects Human Melanocytes Against Oxidative Stress Through Activation of the Nrf2-Antioxidant Response Element Signaling Pathway |
| Star Anise | 📋 | ✍ | ⛔ | | 35521510 | Combinations of plant essential oils and their major compositions inducing mortality and morphological abnormality of Aedes aegypti and Aedes albopictus |
| Star Fuit | 📋 | | ⛔ | | 35359233 | Star fruit extract and C-glycosylated flavonoid components have potential to prevent air pollutant-induced skin inflammation and premature aging |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 38247218 | Ozonated Sunflower Oil (OSO) alleviates inflammatory responses in oxazolone-induced atopic dermatitis (AD)-like mice and LPS- treated RAW 264.7 cells |
| Theaflavins | 📋 | ✍ | | | 35309982 | Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats |
| Thyme Essential Oil | 📋 | | ⛔ | | 29337923 | Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils |
| Urolithins | 📋 | | | | 35567884 | Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 36835861 | Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 37705136 | Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice |
| Wogonin | 📋 | ✍ | ⛔ | | 34688155 | Wogonin inhibits the growth of HT144 melanoma via regulating hedgehog signaling-mediated inflammation and glycolysis |
| Acacetin | 📋 | | | | 35765710 | Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway |
| Aged Garlic | 📋 | ✍ | ⛔ | | 36219767 | Protective effects of volatile components of aged garlic extract against ultraviolet B-induced apoptosis in human skin fibroblasts |
| Almond | 📋 | | ⛔ | | 33673587 | Prospective Randomized Controlled Trial on the Effects of Almonds on Facial Wrinkles and Pigmentation |
| Astragalin | 📋 | | | | 29298652 | Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation |
| Avocado Oil | 📋 | | ⛔ | | 31957954 | Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil |
| Bamboo | 📋 | ✍ | ⛔ | | 36615219 | Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin ( Phyllostachys pubescens) |
| Banana | 📋 | | ⛔ | | 38135229 | Phytochemical profiling, toxicity studies, wound healing, analgesic and anti-inflammatory activities of Musa paradisiaca L. Musaceae (Plantain) stem extract in rats |
| Barberry | 📋 | ✍ | ⛔ | | 38545754 | Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 36223259 | Alternatives to Pyrethroid Resistance: Combinations of Cymbopogon nardus and Ocimum americanum Essential Oils Improve the Bioefficiency Control Against the Adults' Populations of Aedes aegypti (Diptera: Culicidae) |
| Black Tea Polyphenols | 📋 | | | | 37781120 | Ameliorative effect of black tea extract on the skin of D-galactose-induced aging mice |
| Boric Acid | 📋 | ✍ | ⛔ | | 37830831 | Success in treating wounds with local boric acid: a case study |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 35695741 | Photoprotective effects of sweet potato leaf polyphenols and caffeic acid against UV-induced skin-damage in BALB/C nude mice |
| Camphor | 📋 | ✍ | ⛔ | | 37175177 | The Mosquito Larvicidal Activity of Lignans from Branches of Cinnamomum camphora chvar. Borneol |
| CAPE | 📋 | | | | 38111127 | The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375) |
| Cardamom | 📋 | ✍ | ⛔ | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Chlorella | 📋 | ✍ | ⛔ | | 36815029 | Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing |
| Cinnamic Acid | 📋 | | | | 38409197 | Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation |
| Cordycepin | 📋 | | | | 36881050 | Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration |
| Cornus | 📋 | | | | 38705031 | Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects |
| Coumaric acid | 📋 | | | | 38019336 | In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431) |
| Creatine | 📋 | ✍ | ⛔ | | 34836359 | Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts |
| Date | 📋 | | ⛔ | | 37692010 | Anti-inflammatory and antibacterial potential of Ajwa date ( Phoenix dactylifera L.) extract in burn infection |
| Delphinidin | 📋 | | | | 34825313 | Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease |
| Echinacoside | 📋 | | | | 37929119 | Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway |
| Eclipta Alba | 📋 | ✍ | | | 38202343 | Unlocking Therapeutic Potential: Comprehensive Extraction, Profiling, and Pharmacological Evaluation of Bioactive Compounds from Eclipta alba (L.) Hassk. for Dermatological Applications |
| Egg | 📋 | | ⛔ | | 38373195 | Egg White Peptides Accelerating the Wound Healing Process Through Modulating the PI3K-AKT Pathway: A Joint Analysis of Transcriptomic and Proteomic |
| Eucalyptol | 📋 | | | | 36336343 | Topical Eucalyptol Ointment Accelerates Wound Healing and Exerts Antioxidant and Anti-Inflammatory Effects in Rats' Skin Burn Model |
| Flaxseed | 📋 | ✍ | ⛔ | | 33299521 | Were our Ancestors Right in Using Flax Dressings? Research on the Properties of Flax Fibre and Its Usefulness in Wound Healing |
| Frankincense Essential Oil | 📋 | | ⛔ | | 31965826 | Insecticidal activity of two essential oils used in perfumery (ylang ylang and frankincense) |
| GABA | 📋 | ✍ | ⛔ | | 37524442 | The Effect of γ-Aminobutyric Acid Intake on UVB- Induced Skin Damage in Hairless Mice |
| Geniposide | 📋 | | | | 38652958 | Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF-κB p65 signaling pathway and MMP9 |
| Ginger | 📋 | ✍ | ⛔ | | 35294085 | β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts |
| Ginger extract | 📋 | ✍ | ⛔ | | 33126621 | The Influence of Hemp Extract in Combination with Ginger on the Metabolic Activity of Metastatic Cells and Microorganisms |
| Ginkgetin | 📋 | | | | 16651744 | Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation |
| Ginkgolides | 📋 | | | | 36731645 | γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress |
| Glycerin | 📋 | ✍ | ⛔ | | 36973988 | Reduction of wrinkles: From a computational hypothesis to a clinical, instrumental, and biological proof |
| Green Tea | 📋 | ✍ | ⛔ | | 25643794 | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
| Hawthorn | 📋 | ✍ | ⛔ | | 31353662 | Protective effects of hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32685759 | Varicose veins and occupational health: symptoms, treatment and prevention |
| Icariin | 📋 | ✍ | | | 37602424 | Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis |
| Icaritin | 📋 | | | | 34825483 | Icaritin alleviates docetaxel-induced skin injury by suppressing reactive oxygen species via estrogen receptors |
| Isorhamnetin | 📋 | | | | 37273758 | Isorhamnetin attenuates the proliferation, invasion, migration and fibrosis of keloid fibroblasts by targeting S1PR1 |
| Jujube | 📋 | | ⛔ | | 38094286 | The Added-on of Ziziphus jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial |
| Krill Oil | 📋 | ✍ | ⛔ | | 37755092 | Krill Oil's Protective Benefits against Ultraviolet B-Induced Skin Photoaging in Hairless Mice and In Vitro Experiments |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 37025967 | Expression of VEGF and CD-31 in traumatic ulcer of diabetic Wistar rats after application of Citrus limon peel essential oil |
| Lemongrass | 📋 | ✍ | ⛔ | | 38399374 | Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review |
| Lime Essential Oil | 📋 | ✍ | ⛔ | | 35598364 | Assessment of safety and health-benefits of Citrus hystrix DC. peel essential oil, with regard to its bioactive constituents in an in vitro model of physiological and pathological skin conditions |
| Linalool | 📋 | | ⛔ | | 35991888 | A combination of linalool and linalyl acetate synergistically alleviates imiquimod-induced psoriasis-like skin inflammation in BALB/c mice |
| Lingonberry | 📋 | | ⛔ | | 36235484 | Proanthocyanidins from Vaccinium vitis-idaea L. Leaves: Perspectives in Wound Healing and Designing for Topical Delivery |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 34808417 | α-linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 36359407 | Alpha-Lipoic Acid Supplementation Restores Early Age-Related Sensory and Endothelial Dysfunction in the Skin |
| Lychee | 📋 | | ⛔ | | 32089252 | Formulation and clinical evaluation of the standardized Litchi chinensis extract for skin hyperpigmentation and aging treatments |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 24952269 | Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells |
| Osmanthus | 📋 | ✍ | ⛔ | | 38449662 | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| Pear | 📋 | | ⛔ | | 38010847 | Unripe Pear Extract Suppresses UVB-Induced Skin Photoaging in Hairless Mice and Keratinocytes |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 29980963 | Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model |
| Phellodendron | 📋 | ✍ | ⛔ | | 36016687 | The Effects of Phellodendron Decoction on Wound Healing of Anal Fistula after Anal Fistulotomy |
| Pineapple | 📋 | ✍ | ⛔ | | 32682706 | Modulatory Activities of Plant Extracts on Jellyfish Cytotoxicity |
| Pomegranate Seed extract | 📋 | | ⛔ | | 36677961 | Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study |
| Proanthocyanidins | 📋 | | | | 37858664 | Grape seed proanthocyanidins regulate mitophagy of endothelial cells and promote wound healing in mice through p-JNK/FOXO3a/ROS signal pathway |
| Red Sage | 📋 | ✍ | ⛔ | | 38558153 | Soluble polyvinylpyrrolidone-based microneedles loaded with Sanguis draconis and Salvia miltiorrhiza for treatment of diabetic wound healing |
| Rose | 📋 | | | | 36080266 | In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 31889869 | Antimicrobial activity of certain natural-based plant oils against the antibiotic-resistant acne bacteria |
| Sage Essential Oil | 📋 | | ⛔ | | 32460189 | Accelerated Healing by Topical Administration of Salvia Officinalis Essential Oil on Pseudomonas Aeruginosa and Staphylococcus Aureus Infected Wound Model |
| Scutellarin | 📋 | | | | 35080332 | Scutellarin potentiates the skin regenerative function of self growth colony, an optimized platelet-rich plasma extract, in cultured keratinocytes through VEGF receptor and MAPK signaling |
| Soy | 📋 | ✍ | ⛔ | | 37373864 | Clinical Efficacy of Topical or Oral Soy Supplementation in Dermatology: A Systematic Review |
| Tangeretin | 📋 | | | | 25924512 | Tangeretin triggers melanogenesis through the activation of melanogenic signaling proteins and sustained extracellular signal- regulated kinase in B16/F10 murine melanoma cells |
| Taurine | 📋 | ✍ | ⛔ | | 37840567 | Taurine accelerates the synthesis of ceramides and hyaluronic acid in cultured epidermis and dermal fibroblasts |
| Tea Polyphenols | 📋 | | | | 37677966 | Tea polyphenols (TPP) as a promising wound healing agent: TPP exerts multiple and distinct mechanisms at different phases of wound healing in a mouse model |
| Terpenoids | 📋 | | | | 38674007 | The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers |
| Tetrahydrocurcumin | 📋 | ✍ | | | 35965981 | Explore the multitarget mechanism of tetrahydrocurcumin preventing on UV-induced photoaging mouse skin |
| Thymol | 📋 | ✍ | ⛔ | | 35848908 | A systematic review and meta-analysis of the effect of thymol as an anti-inflammatory and wound healing agent: A review of thymol effect on inflammation and wound healing: A review of thymol effect on inflammation and wound healing |
| Toothache Plant | 📋 | | | | 34806292 | Improvement of urban eye skin in Chinese female by supramolecular retinol plus acmella oleracea extract-containing product |
| Trehalose | 📋 | | ⛔ | | 36609486 | Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21 |
| TUDCA | 📋 | ✍ | ⛔ | | 34639105 | Tauroursodeoxycholic Acid Decreases Keloid Formation by Reducing Endoplasmic Reticulum Stress as Implicated in the Pathogenesis of Keloid |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 38360911 | In-vivo and in-vitro wound healing and tissue repair effect of Trametes versicolor polysaccharide extract |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 37759526 | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 36047208 | Pyridoxine Has a Potential to Prevent the Appearance of Pigmented Spots: Effects on the Phagocytosis and Differentiation of Keratinocytes |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 37182050 | The Efficacy and Safety of Dr. SKS Hair Booster Serum (a Cocktail of Micronutrients and Multivitamins) in Adult Males and Females With Androgenetic Alopecia: An Open-Label, Non-randomized, Prospective Study |
| Watercress | 📋 | ✍ | ⛔ | | 35215254 | Evaluation of Bioactive Properties of Lipophilic Fractions of Edible and Non-Edible Parts of Nasturtium officinale (Watercress) in a Model of Human Malignant Melanoma Cells |
| White Tea | 📋 | | ⛔ | | 25643794 | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 31965826 | Insecticidal activity of two essential oils used in perfumery (ylang ylang and frankincense) |
| Alfalfa | 📋 | | ⛔ | | 35815838 | The effect of Medicago sativa extract and light on skin hypopigmentation disorders in C57/BL6 mice |
| Amygdalin | 📋 | ✍ | ⛔ | | 38723918 | Amygdalin ameliorates alopecia areata on C3H/HeJ mice by inhibiting inflammation through JAK2/STAT3 pathway |
| Anethole | 📋 | | | | 35521510 | Combinations of plant essential oils and their major compositions inducing mortality and morphological abnormality of Aedes aegypti and Aedes albopictus |
| Apricot Oil | 📋 | | ⛔ | | 31292346 | Chemical Composition and Antioxidant Properties of Oils From the Seeds of Five Apricot (Prunus Armeniaca L.) Cultivars |
| Artichoke | 📋 | ✍ | ⛔ | | 37544953 | Artichoke as a melanoma growth inhibitor |
| Asafoetida | 📋 | ✍ | ⛔ | | 30087798 | Effects of Oleo Gum Resin of Ferula assa-foetida L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts |
| Avocado | 📋 | ✍ | ⛔ | | 35037373 | Avocado Consumption Increased Skin Elasticity and Firmness in Women - A Pilot Study |
| Basil | 📋 | ✍ | ⛔ | | 33424273 | Formulation and evaluation of Ocimum basilicum-based emulgel for wound healing using animal model |
| Bergamot | 📋 | ✍ | ⛔ | | 30847114 | Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 33119413 | Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation |
| Bitter Melon | 📋 | ✍ | ⛔ | | 34903928 | Wound healing by topical application of Momordica charantia L. formulations on mice |
| Blackberry | 📋 | | ⛔ | | 32583541 | A blackberry-dill extract combination synergistically increases skin elasticity |
| Calcium D-Glucarate | 📋 | ✍ | ⛔ | | 26655363 | Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs |
| Carnosol | 📋 | | | | 29476131 | The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation |
| Castor Oil | 📋 | ✍ | ⛔ | | 37927123 | Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single-arm clinical trial |
| Catalpol | 📋 | | | | 38041954 | Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 37830196 | Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy |
| Crocetin | 📋 | | | | 27452919 | Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo |
| Cyanidin | 📋 | ✍ | | | 28527426 | Malvidin and cyanidin derivatives from açai fruit (Euterpe oleracea Mart.) counteract UV-A-induced oxidative stress in immortalized fibroblasts |
| D-Limonene | 📋 | ✍ | ⛔ | | 36063024 | Limonene protects human skin keratinocytes against UVB-induced photodamage and photoaging by activating the Nrf2-dependent antioxidant defense system |
| Dill | 📋 | | ⛔ | | 37788642 | Dill extract preserves dermal elastic fibers network and functionality. Implication of elafin |
| Essential Fatty Acids | 📋 | ✍ | | | 18477332 | Efficacy of an essential fatty acid-enriched diet in managing canine atopic dermatitis: a randomized, single-blinded, cross-over study |
| Fenugreek | 📋 | ✍ | ⛔ | | 37907366 | Effect of hydroalcoholic extract of Trigonella foenum-graecum leaves on wound healing in type 1 diabetic rats |
| Folate | 📋 | ✍ | ⛔ | | 34894370 | Macronutrient and micronutrient intake of individuals with diabetic foot ulceration: A short report |
| Genipin | 📋 | | | | 35677301 | Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review |
| Glycyrrhetinic Acid | 📋 | | | | 34792270 | Evaluation of a new-formula shampoo containing 6% glycyrrhetinic acid complex for scalp seborrheic dermatitis: A pilot study |
| Guggul | 📋 | ✍ | ⛔ | | 36113432 | Determination of the Effectiveness of Topical Product of Commiphora Mukul Oleo Gum Resin on Dermal Wound Healing: An Experimental Study |
| Helichrysum Essential Oil | 📋 | ✍ | ⛔ | | 36867611 | Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier |
| HMB | 📋 | ✍ | ⛔ | | 36796413 | Long-term supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine for pressure ulcer in sedentary older adults: a retrospective matched case-control study |
| Hypericin | 📋 | | | | 37956650 | Effects of Hypericin on Cultured Primary Normal Human Dermal Fibroblasts Under Increased Oxidative Stress |
| Hyperoside | 📋 | | | | 37373060 | Hyperoside as a UV Photoprotective or Photostimulating Compound-Evaluation of the Effect of UV Radiation with Selected UV-Absorbing Organic Compounds on Skin Cells |
| Inulin | 📋 | ✍ | ⛔ | | 38282163 | Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders |
| Isoquercitrin | 📋 | | | | 38337181 | Protective effect of isoquercitrin on UVB-induced injury in HaCaT cells and mice skin through anti-inflammatory, antioxidant, and regulation of MAPK and JAK2-STAT3 pathways |
| Jasmine | 📋 | | ⛔ | | 35584807 | Efficacy of silk sericin and Jasminum grandiflorum L. leaf extract on skin injuries induced by burn in mice |
| Kale | 📋 | | | | 35739968 | Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients |
| L-Lysine | 📋 | ✍ | ⛔ | | 37457650 | Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study |
| L-Methionine | 📋 | ✍ | ⛔ | | 37357646 | Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study |
| L-Theanine | 📋 | ✍ | ⛔ | | 34542664 | L-Theanine inhibits melanoma cell growth and migration via regulating expression of the clock gene BMAL1 |
| Lauric Acid | 📋 | ✍ | | | 32390309 | A Retrospective Assessment and Comparison of the Effectiveness of Benzoyl Peroxide, the Combination of Topical Niacinamide, Gallic Acid and Lauric Acid and the Combination of Benzoyl Peroxide and Erythromycin in Acne Vulgaris |
| Liquiritigenin | 📋 | | | | 36575875 | Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption |
| Lutein | 📋 | ✍ | ⛔ | | 37012890 | Lutein attenuates Propionibacterium acnes-induced inflammation by inhibiting pyroptosis of human keratinocyte cells via TLR4/NLRP3/Caspase-1 pathway |
| Magnolia | 📋 | ✍ | ⛔ | | 37955529 | Effects of Magnoliae Flos on Atopic Dermatitis-Like Inflammation Evaluated via Extracellular Signal-regulated Kinase or Signal Transducers and Activators of Transcription 1/3 Signalling Pathways |
| Maitake Mushrooms | 📋 | | ⛔ | | 38053833 | Extracts of Grifola frondosa inhibit the MAPK signaling pathways involved in keratinocyte inflammation and ameliorate atopic dermatitis |
| Malvidin | 📋 | | | | 28527426 | Malvidin and cyanidin derivatives from açai fruit (Euterpe oleracea Mart.) counteract UV-A-induced oxidative stress in immortalized fibroblasts |
| Mandarin | 📋 | | | | 35405965 | Clinical Evidence of Effects of Green Mandarin (Putgyul) Extract on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study |
| Mandarin Essential Oil | 📋 | | ⛔ | | 36501374 | Citrus reticulata Leaves Essential Oil as an Antiaging Agent: A Comparative Study between Different Cultivars and Correlation with Their Chemical Compositions |
| Marjoram Essential Oil | 📋 | | ⛔ | | 32121614 | Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region |
| Morusin | 📋 | | | | 38071943 | A dual mechanism with H2S inhibition and membrane damage of morusin from Morus alba Linn. against MDR-MRSA |
| Myrrh Essential Oil | 📋 | | ⛔ | | 35745024 | Phytochemical Composition of Commiphora Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 29159502 | Antifungal activity of Myrtus communis against Malassezia sp. isolated from the skin of patients with pityriasis versicolor |
| NAD | 📋 | | | | 37216171 | NAD+ administration profoundly decreases UVC-induced skin damage by attenuating oxidative stress, inflammation, DNA damage and apoptosis |
| Neferine | 📋 | | | | 34361003 | Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice |
| Noni | 📋 | | ⛔ | | 36559008 | Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies |
| Oats | 📋 | | ⛔ | | 38139104 | Oat ( Avena sativa L.) Sprouts Restore Skin Barrier Function by Modulating the Expression of the Epidermal Differentiation Complex in Models of Skin Irritation |
| Oyster | 📋 | | ⛔ | | 38234916 | Proteins extracted from pearl oyster ( Pinctada martensii) with efficient accelerated wound healing in vitro through promoting cell proliferation, migration, and collagen formation |
| Oyster Mushrooms | 📋 | | ⛔ | | 38595484 | Exploring the Role of Pleurotus Ostreatus as an Ointment Formulation in Inducing Wound Healing in Mice Skin |
| Palmarosa Essential Oil | 📋 | | ⛔ | | 35320495 | p-Menthadienols-rich essential oil from Cymbopogon martini ameliorates skin inflammation |
| Papain | 📋 | ✍ | ⛔ | | 32610228 | Papain Immobilized on Alginate Membrane for Wound Dressing Application |
| Parsley | 📋 | | ⛔ | | 38338356 | Exploring the Therapeutic Efficacy of Parsley ( Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| Parthenolide | 📋 | | | | 38461633 | A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 29736153 | Tabetri™ ( Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| PEA | 📋 | ✍ | ⛔ | | 38408443 | Efficacy of topical palmitoylethanolamide (Levagen+) for the management of eczema symptoms: A double blind, comparator controlled, randomized clinical trial |
| Peppermint | 📋 | ✍ | ⛔ | | 32425029 | Evaluation of the effectiveness and safety of peppermint peel (PMP) soft peeling for skin ageing |
| Pistachio | 📋 | ✍ | ⛔ | | 35439545 | In vivo wound healing effect of Italian and Algerian Pistacia vera L. resins |
| Poria Mushrooms | 📋 | ✍ | | | 38301984 | Bioactive triterpenoid compounds of Poria cocos (Schw.) Wolf in the treatment of diabetic ulcers via regulating the PI3K-AKT signaling pathway |
| Rosehip | 📋 | ✍ | ⛔ | | 38188083 | Hair Growth-Promoting Effects of Rosehip ( Rosa canina L.) Seed Oil in C57BL/6 Mice |
| Safflower | 📋 | ✍ | ⛔ | | 33204394 | Antioxidant and Antimicrobial Potentials of Seed Oil from Carthamus tinctorius L. in the Management of Skin Injuries |
| SAMe | 📋 | ✍ | ⛔ | | 36638586 | S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas |
| Schisandrins | 📋 | | | | 37622448 | Schisandrin B Inhibits Cell Viability and Malignant Progression of Melanoma Cells via Wnt/β-catenin Signaling Pathway |
| Sesamin | 📋 | ✍ | | | 37545137 | Sesamin attenuates UVA-induced keratinocyte injury via inhibiting ASK-1-JNK/p38 MAPK pathways |
| Shea | 📋 | | ⛔ | | 35516971 | The Efficacy and Tolerability of Turmeric and Salicylic Acid in Psoriasis Treatment |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 27483228 | Chemical Composition and Inhibitory Effect of Lentinula edodes Ethanolic Extract on Experimentally Induced Atopic Dermatitis in Vitro and in Vivo |
| Sirtuin Activators | 📋 | | | | 37445960 | The Role of Sirtuins in the Pathogenesis of Psoriasis |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 30417760 | Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice |
| Soy Protein | 📋 | ✍ | ⛔ | | 37836398 | Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial |
| Spearmint | 📋 | | ⛔ | | 19585478 | Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial |
| Sunflower | 📋 | | ⛔ | | 37727996 | Protective effect of Helianthus annuus seed byproduct extract on ultraviolet radiation-induced injury in skin cells |
| Tea | 📋 | | | | 37396975 | Coffee, Citrus, and Alcohol: A Review of What We Drink and How it May Affect our Risk for Skin Cancer |
| Thyme | 📋 | ✍ | ⛔ | | 33169920 | A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial |
| Trans-Resveratrol | 📋 | | | | 33336760 | The potential role of trans-resveratrol/carboxymethylated (1.3/1.6)-β-d-glucan minimizing symptoms and improve healing after functional endoscopic sinus surgery |
| Vitamin B Complex | 📋 | | ⛔ | | 37063401 | Vitamin B group levels and supplementations in dermatology |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 37182050 | The Efficacy and Safety of Dr. SKS Hair Booster Serum (a Cocktail of Micronutrients and Multivitamins) in Adult Males and Females With Androgenetic Alopecia: An Open-Label, Non-randomized, Prospective Study |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 31691401 | The potential role of B5: A stitch in time and switch in cytokine |
| Vitamin K | 📋 | ✍ | ⛔ | | 36532748 | Effect of vitamin K on wound healing: A systematic review and meta-analysis based on preclinical studies |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 33390552 | Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases |
| Vitexin | 📋 | | | | 37406508 | Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice |
| Whey Protein | 📋 | ✍ | ⛔ | | 37564458 | The Topical Formulation of Whey Protein for the Prevention of Pressure Ulcers in Critically Ill Patients: A Novel Intervention in a Randomized-Controlled Clinical Trial |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 35047439 | Pre-Clinical Evaluation of Proprietary Lutein, Zeaxanthin, and Rosemary Formulation for Its Dermal Protective Activity in Male Swiss Albino Mice |
| 5-HTP | 📋 | ✍ | ⛔ | | 30221419 | 5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis probably through inhibition of IL-17A production and keratinocyte activation |
| Aloesin | 📋 | | | | 28478809 | Aloesin From Aloe Vera Accelerates Skin Wound Healing by Modulating MAPK/Rho and Smad Signaling Pathways in Vitro and in Vivo |
| Amino Acids | 📋 | | | | 34420200 | Effect of Vitamin-Containing Amino Acid Supplements on Menopausal Symptoms and Age-Related Skin Changes: A Randomised, Double-Blind, Placebo-Controlled Study |
| Anthocyanidins | 📋 | | | | 28680383 | Antiproliferative and Proapoptotic Activities of Anthocyanin and Anthocyanidin Extracts From Blueberry Fruits on B16-F10 Melanoma Cells |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 26881006 | The Effect of External Apple Vinegar Application on Varicosity Symptoms, Pain, and Social Appearance Anxiety: A Randomized Controlled Trial |
| Arjuna | 📋 | ✍ | ⛔ | | 36238547 | Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro |
| Ashitaba | 📋 | ✍ | ⛔ | | 29980517 | The Ashitaba ( Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K |
| Asparagus | 📋 | | ⛔ | | 37454069 | Wound healing effects of Asparagus lucidus Lindl extract through the phosphorylation of ERK1/2 |
| Azadirachtin | 📋 | | | | 32450387 | Melanogenesis-inhibitory activities of limonoids and tricyclic diterpenoids from Azadirachta indica |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38558933 | Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions |
| Bay Leaf | 📋 | | ⛔ | | 21188975 | Lauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-κB activation |
| Bee Pollen | 📋 | ✍ | ⛔ | | 32012913 | Bee Products in Dermatology and Skin Care |
| Beer | 📋 | | | | 23802910 | Beer and beer compounds: physiological effects on skin health |
| Bentonite Clay | 📋 | ✍ | ⛔ | | 26831423 | Comparing the effects of Bentonite & Calendula on the improvement of infantile diaper dermatitis: A randomized controlled trial |
| Bergamottin | 📋 | | | | 34168462 | Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 33170524 | Aquagenic pruritus in an adolescent effectively managed with β-alanine supplementation |
| Bilobalide | 📋 | | | | 31520488 | Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks |
| Biochanin A | 📋 | | | | 21597196 | In Vitro and in Vivo Melanogenesis Inhibition by Biochanin A From Trifolium Pratense |
| Black Cohosh | 📋 | ✍ | ⛔ | | 34260808 | Effects of a Combination of Botanical Actives on Skin Health and Antioxidant Status in Post-menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 29770504 | Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells |
| Boron | 📋 | ✍ | ⛔ | | 26770156 | Nothing Boring About Boron |
| Camphor Essential Oil | 📋 | | ⛔ | | 30582219 | Camphor white oil induces tumor regression through cytotoxic T cell-dependent mechanisms |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 29786144 | Self-initiated use of topical cannabidiol oil for epidermolysis bullosa |
| Caraway | 📋 | | ⛔ | | 36239922 | Wound healing effect of Carum carvi L. on the incised skin wound in male rats: Histopathology, total protein and biomechanical evaluations |
| Cauliflower | 📋 | | ⛔ | | 30414245 | Efficacy of two plant extracts against acne vulgaris: Initial results of microbiological tests and cell culture studies |
| Celery | 📋 | | ⛔ | | 32202321 | Anti-atopic Dermatitis Effects of Hydrolyzed Celery Extract in Mice |
| Chili Pepper | 📋 | | ⛔ | | 34646883 | Antibacterial and Therapeutic Potentials of the Capsicum annuum Extract against Infected Wound in a Rat Model with Its Mechanisms of Antibacterial Action |
| Citicoline | 📋 | ✍ | ⛔ | | 26360650 | Influence of Cdp-Choline Administration on Early Burn Edema in Rats |
| Citral | 📋 | | | | 31687359 | Insecticidal activities of Citrus aurantifolia essential oil against Aedes aegypti (Diptera: Culicidae) |
| Coriander | 📋 | | ⛔ | | 35440935 | Effect of the supplementation of virgin coriander seed oil on reducing reactivity in healthy women with sensitive skin: a randomized double-blind placebo-controlled pilot clinical study |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 35449437 | Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway |
| Costus | 📋 | ✍ | ⛔ | | 33321189 | The anti-UV properties of Saussurea involucrate Matsum. & Koidz. Via regulating PI3K/Akt pathway in B16F10 cells |
| Cumin | 📋 | | ⛔ | | 38711343 | Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms |
| Daidzein | 📋 | ✍ | ⛔ | | 32277673 | Anticancer effects of Daidzein against the human melanoma cell lines involves cell cycle arrest, autophagy and deactivation of PI3K/AKT signalling pathways |
| Daisy | 📋 | | ⛔ | | 34175580 | Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects |
| Deodar Cedar | 📋 | | | | 37064944 | Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties |
| DHEA | 📋 | ✍ | ⛔ | | 20698844 | Skin Responses to Topical Dehydroepiandrosterone: Implications in Antiageing Treatment? |
| Diallyl Sulfide | 📋 | | | | 33867704 | Amelioration of Combination of Paclitaxel and Di Allyl Sulfide on the Alterations of Bcl2, P53 and Apoptosis Changes Against 7,12 Di Methyl Benz (A) Anthracene Induced Skin Cancer in Experimental Animals |
| Diallyl Trisulfide | 📋 | | | | 38280077 | Synergistic inhibitory actions of resveratrol, epigallocatechin-3-gallate, and diallyl trisulfide against skin cancer cell line A431 through mitochondrial caspase dependent pathway: a combinational drug approach |
| Diosgenin | 📋 | | | | 36902475 | Effect of Chitosan-Diosgenin Combination on Wound Healing |
| Dragon Fruit | 📋 | | ⛔ | | 37774168 | Topical Cream Derived From Hylocereus polyrhizus (Red Dragon Fruit) Extract Accelerates Wound Healing Through Increased Hydroxyproline and Fibroblast Growth Factor 2 Levels: A Pilot Study |
| EDTA | 📋 | ✍ | ⛔ | | 26392023 | Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn |
| Eggplant | 📋 | | ⛔ | | 35061237 | Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 33240007 | Synergistic effect of fennel essential oil and hydrogen peroxide on bacterial biofilm |
| Fir Needle Oil | 📋 | | ⛔ | | 37688255 | Antimicrobial Wound Dressings based on Bacterial Cellulose and Independently Loaded with Nutmeg and Fir Needle Essential Oils |
| Forskolin | 📋 | ✍ | ⛔ | | 24838074 | Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation |
| Geraniin | 📋 | | | | 21036574 | Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts |
| Geranium | 📋 | | | | 35579150 | Wound Healing properties of Pelargonium Graveolens L'Hér Extract Lipogel: In-Vivo Evaluation in an Animal Burn Model |
| Ginger Essential Oil | 📋 | ✍ | | | 29355275 | Effects of volatile oil from ginger on the murine B16 melanoma cells and its mechanism |
| Glycine | 📋 | ✍ | ⛔ | | 37805752 | [Effects and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats] |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 35505451 | Protective Effects of Grapefruit Essential Oil against Staphylococcus Aureus-Induced Inflammation and Cell damage in Human Epidermal Keratinocytes |
| Guava | 📋 | | ⛔ | | 36559626 | Guava ( Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities |
| Hazelnut | 📋 | | ⛔ | | 28208804 | Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 34088571 | Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 35392596 | UHPLC-MS/MS-GNPS based phytochemical investigation of Equisetum arvense L. And evaluation of cytotoxicity against human melanoma and ovarian cancer cells |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36639978 | Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis |
| Isoflavones | 📋 | ✍ | ⛔ | | 38586368 | Anti-cancer mechanisms of natural isoflavones against melanoma |
| Jasmine Essential Oil | 📋 | | | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Jojoba Oil | 📋 | ✍ | ⛔ | | 34957578 | An updated review on efficacy and benefits of sweet almond, evening primrose and jojoba oils in skin care applications |
| Kimchi | 📋 | | ⛔ | | 34737993 | Effect of Lactic Acid Strains Isolated from Kimchi on Atopic Dermatitis and Immunomodulation in NC/Nga Mice |
| L-Histidine | 📋 | ✍ | ⛔ | | 33000160 | l-Histidine Supplementation in Adults and Young Children with Atopic Dermatitis (Eczema) |
| L-Proline | 📋 | ✍ | ⛔ | | 33439085 | Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 38318507 | Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis |
| Lavender | 📋 | ✍ | ⛔ | | 33066851 | The effect of Lavender on pain and healing of episiotomy: A systematic review |
| Lemon | 📋 | | ⛔ | | 35520688 | Effect of lemon peel flavonoids on UVB-induced skin damage in mice |
| Ligustilide | 📋 | | | | 38183407 | Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba |
| Limonin | 📋 | | | | 36558517 | Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 35446523 | Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts |
| Long Pepper | 📋 | | ⛔ | | 34699564 | Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition |
| Loquat | 📋 | ✍ | ⛔ | | 28492484 | The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder |
| Maca Root | 📋 | ✍ | ⛔ | | 36051487 | Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats |
| Malva Sylvestris | 📋 | | ⛔ | | 33100212 | Efficacy of Short Term Topical Malva Sylvestris L. Cream in Pediatric Patients with Atopic Dermatitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial |
| Manganese | 📋 | ✍ | ⛔ | | 37751003 | Association between blood heavy metal concentrations and skin cancer in the National Health and Nutrition Examination Survey, 2011-2018 |
| Mango Leaf | 📋 | | ⛔ | | 35784391 | Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells |
| Millet | 📋 | | | | 37229245 | Millet seed oil activates β-catenin signaling and promotes hair growth |
| Mugwort | 📋 | | ⛔ | | 35351963 | Repellency and insecticidal activity of seven Mugwort (Artemisia argyi) essential oils against the malaria vector Anopheles sinensis |
| Neohesperidin | 📋 | | | | 35150043 | Efficacy of a topical serum containing l-ascorbic acid, neohesperidin, pycnogenol, tocopherol and hyaluronic acid in relation to skin aging signs |
| Nimbolide | 📋 | | | | 34414905 | Natural product topical therapy in mitigating imiquimod-induced psoriasis-like skin inflammation-underscoring the anti-psoriatic potential of Nimbolide |
| Nootkatone | 📋 | | | | 33925333 | Nootkatone Is an Effective Repellent against Aedes aegypti and Aedes albopictus |
| Nuciferine | 📋 | | | | 37813639 | Molecular docking Study of Nuciferine as a Tyrosinase Inhibitor and Its Therapeutic Potential for Hyperpigmentation |
| Nutmeg | 📋 | ✍ | ⛔ | | 35497187 | Excito-repellency of Myristica fragrans Houtt. and Curcuma longa L. extracts from Southern Thailand against Aedes aegypti (L.) |
| Nutmeg Essential Oil | 📋 | | ⛔ | | 37688255 | Antimicrobial Wound Dressings based on Bacterial Cellulose and Independently Loaded with Nutmeg and Fir Needle Essential Oils |
| Oak Acorn | 📋 | ✍ | ⛔ | | 34983480 | Protective effects of Quercus acuta Thunb. fruit extract against UVB-induced photoaging through ERK/AP-1 signaling modulation in human keratinocytes |
| Oak Gall | 📋 | ✍ | ⛔ | | 34382850 | Quercus infectoria gall extract aids wound healing in a streptozocin-induced diabetic mouse model |
| Okra | 📋 | | ⛔ | | 34801610 | A comprehensive study to evaluate the wound healing potential of okra (Abelmoschus esculentus) fruit |
| Oleic Acid | 📋 | | ⛔ | | 34040528 | Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 31979308 | Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases |
| Oregano | 📋 | ✍ | ⛔ | | 33080917 | Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage |
| Paprika | 📋 | | ⛔ | | 35387919 | Effects of Oral Supplementation with Paprika Xanthophylls on Human Skin Moisture |
| Peach | 📋 | | ⛔ | | 29399294 | Topical or oral treatment of peach flower extract attenuates UV-induced epidermal thickening, matrix metalloproteinase-13 expression and pro-inflammatory cytokine production in hairless mice skin |
| Peas | 📋 | | ⛔ | | 36834534 | Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis |
| Perilla | 📋 | ✍ | | | 35566346 | The Essential Oil Derived from Perilla frutescens (L.) Britt. Attenuates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice |
| Phloretin | 📋 | | | | 19146606 | Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 38408759 | Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation |
| Phytoestrogens | 📋 | | ⛔ | | 33242128 | Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin |
| Phytosterols | 📋 | | | | 37075671 | The elucidation of structure-activity and structure-permeation relationships for the cutaneous delivery of phytosterols to attenuate psoriasiform inflammation |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 22155393 | Appraisal on the wound healing and anti-inflammatory activities of the essential oils obtained from the cones and needles of Pinus species by in vivo and in vitro experimental models |
| Piperlongumine | 📋 | | | | 37830157 | Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells |
| Postbiotics | 📋 | | | | 38312314 | Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review |
| Potato | 📋 | | ⛔ | | 38328356 | Effects of Solanum tuberosum L. ointment on second-degree burns in mice |
| Progesterone | 📋 | ✍ | ⛔ | | 33527841 | Impact of progesterone on skin and hair in menopause - a comprehensive review |
| Protein | 📋 | ✍ | ⛔ | | 36238375 | Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 35636653 | Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification |
| Psyllium | 📋 | ✍ | ⛔ | | 36897894 | Antibacterial activity of ethanolic extracts of Plantago major leaves against Pseudomonas aeruginosa from burn infections |
| PUFA | 📋 | | | | 35684045 | Fatty Acid Supplementation Affects Skin Wound Healing in a Rat Model |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 30047218 | A red pumpkin seed extract reduces melanosome transfer to keratinocytes by activation of Nrf2 signaling |
| Radish | 📋 | | ⛔ | | 38543055 | Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction |
| Rhodiola | 📋 | ✍ | ⛔ | | 37292297 | In vitro effects of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in normal and malignant human skin cells |
| Rose Essential Oil | 📋 | | | | 36651329 | Effects of aromatherapy with Rosa damascene and lavender on pain and anxiety of burn patients: A systematic review and meta-analysis |
| Rosehip Seed Oil | 📋 | | ⛔ | | 36559109 | In Vitro and In Vivo Characteristics of Olive Oil as Excipient for Topical Administration |
| Safranal | 📋 | | | | 33615006 | The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review |
| Salt | 📋 | | ⛔ | | 34929811 | The effectiveness of 7% table salt concentration test to increase collagen in the healing process of wound |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 35325869 | Aromatherapy Massage for Relief of Pruritus and Stress in Older Women |
| Scutellarein | 📋 | | | | 35771623 | Scutellarein Attenuates Atopic Dermatitis by Selectively Inhibiting Transient Receptor Potential Vanilloid 3 |
| Seafood | 📋 | | | | 32770320 | Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus |
| Serrapeptase | 📋 | ✍ | ⛔ | | 33653320 | Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial |
| Sesame | 📋 | ✍ | ⛔ | | 17524128 | Clinical and instrumental study of the efficacy of a new sebum control cream |
| Sesamol | 📋 | | | | 34906777 | Route of intracellular uptake and cytotoxicity of sesamol, sesamin, and sesamolin in human melanoma SK-MEL-2 cells |
| Sesamolin | 📋 | | | | 34906777 | Route of intracellular uptake and cytotoxicity of sesamol, sesamin, and sesamolin in human melanoma SK-MEL-2 cells |
| Shallot | 📋 | | ⛔ | | 35684272 | Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot ( Allium ascalonicum L.) Extract |
| Shilajit | 📋 | ✍ | ⛔ | | 33922346 | Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 33073124 | A Facile Synthesis of Self-Catalytic Hydrogel Films and Their Application as a Wound Dressing Material Coupled with Natural Active Compounds |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 38545754 | Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial |
| Spermidine | 📋 | | | | 36008447 | A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins |
| Spices | 📋 | | | | 37687080 | Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy |
| Spikenard | 📋 | ✍ | ⛔ | | 21716625 | Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC |
| Spinach | 📋 | | ⛔ | | 37696865 | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
| Stigmasterol | 📋 | | | | 38539913 | Stigmasterol Exerts an Anti-Melanoma Property through Down-Regulation of Reactive Oxygen Species and Programmed Cell Death Ligand 1 in Melanoma Cells |
| Strawberry | 📋 | ✍ | ⛔ | | 28613256 | Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage |
| Sulfur | 📋 | ✍ | ⛔ | | 34068523 | Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-κB Signaling in CCD-986Sk Skin Fibroblasts |
| Sweet Potato | 📋 | | ⛔ | | 35695741 | Photoprotective effects of sweet potato leaf polyphenols and caffeic acid against UV-induced skin-damage in BALB/C nude mice |
| Tamarind | 📋 | | ⛔ | | 36616217 | Comparative Metabolic Study of Tamarindus indica L.'s Various Organs Based on GC/MS Analysis, In Silico and In Vitro Anti-Inflammatory and Wound Healing Activities |
| Tangerine | 📋 | | ⛔ | | 36575892 | Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin |
| Tannic Acid | 📋 | ✍ | ⛔ | | 32858160 | Tannic Acid, A Promising Anti-Photoaging Agent: Evidences of its Antioxidant and Anti-Wrinkle Potentials, and its Ability to Prevent Photodamage and MMP-1 Expression in L929 Fibroblasts Exposed to UVB |
| UDCA | 📋 | ✍ | ⛔ | | 38490296 | Ursodeoxycholic acid alleviates atopic dermatitis-associated inflammatory responses in HaCaT and RBL-2H3 cells and DNCB/DFE-treated mice |
| Vegetables | 📋 | | | | 37630784 | Vegetable as a Source of Bioactive Compounds with Photoprotective Properties: Implication in the Aging Process |
| Vitex | 📋 | ✍ | ⛔ | | 34260808 | Effects of a Combination of Botanical Actives on Skin Health and Antioxidant Status in Post-menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Wasabi | 📋 | | ⛔ | | 34207583 | Flavonoid and Phenolic Acids Content and In Vitro Study of the Potential Anti-Aging Properties of Eutrema japonicum (Miq.) Koidz Cultivated in Wasabi Farm Poland |
| Water Chestnut | 📋 | ✍ | ⛔ | | 33590040 | Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk |
| White Mushrooms | 📋 | | ⛔ | | 37356609 | A novel cell-wall polysaccharide derived from the stipe of Agaricus bisporus inhibits mouse melanoma proliferation and metastasis |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 33806146 | Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.) |
| Wormwood Essential Oil | 📋 | | ⛔ | | 28845008 | [Therapeutic effect of Artemisia argyi on oral ulcer in rats] |
| Xylitol | 📋 | ✍ | ⛔ | | 34771112 | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| Yogurt | 📋 | | ⛔ | | 38170675 | Yogurt Alleviates Imiquimod-Induced Psoriasis by Activating the Lactate/GPR81 Signaling Axis in Mice |
| Yohimbine | 📋 | ✍ | | | 35840473 | Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways |
| Zingerone | 📋 | | | | 29117507 | Zingerone protects keratinocyte stem cells from UVB-induced damage |
